:: Volume 27, Issue 92 (5-2009) ::
3 2009, 27(92): 30-36 Back to browse issues page
Intravaginal Metronidazole for the Prevention of Post-Cesarean Endometritis
Leili sekhavat, افسرالسادات tabatabaei
Abstract:   (18 Views)
Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"__AWT_NOKT_COMMA__ mso-tstyle-rowband-size:0__AWT_NOKT_COMMA__ mso-tstyle-colband-size:0__AWT_NOKT_COMMA__ mso-style-noshow:yes__AWT_NOKT_COMMA__ mso-style-priority:99__AWT_NOKT_COMMA__ mso-style-qformat:yes__AWT_NOKT_COMMA__ mso-style-parent:""__AWT_NOKT_COMMA__ mso-padding-alt:0cm 5.4pt 0cm 5.4pt__AWT_NOKT_COMMA__ mso-para-margin:0cm__AWT_NOKT_COMMA__ mso-para-margin-bottom:.0001pt__AWT_NOKT_COMMA__ mso-pagination:widow-orphan__AWT_NOKT_COMMA__ font-size:11.0pt__AWT_NOKT_COMMA__ font-family:"Calibri","sans-serif"__AWT_NOKT_COMMA__ mso-ascii-font-family:Calibri__AWT_NOKT_COMMA__ mso-ascii-theme-font:minor-latin__AWT_NOKT_COMMA__ mso-fareast-font-family:"Times New Roman"__AWT_NOKT_COMMA__ mso-fareast-theme-font:minor-fareast__AWT_NOKT_COMMA__ mso-hansi-font-family:Calibri__AWT_NOKT_COMMA__ mso-hansi-theme-font:minor-latin__AWT_NOKT_COMMA__ mso-bidi-font-family:Arial__AWT_NOKT_COMMA__ mso-bidi-theme-font:minor-bidi__AWT_NOKT_COMMA__} Background: Postpartum endometritis is an important cause of maternal morbidity after cesarean section. Prophylactic antibiotic therapy reduces the risk by approximately 60%. The purpose of this study was to estimate the efficacy of preoperative administration of intra-vaginal Metronidazole for the prevention of post-cesarean endometritis. Methods: This double-blind, case-control, randomized trial included 292 patients whowere going to undergo elective cesarean deliveries. Patients were randomly selected to receive either 5 g of Metronidazole gel intra-vaginally (n = 146) or matching placebo (n = 146) before the initiation of the cesarean. Patients with chorioamnionitis, suspected allergy to Metronidazole, and/or PROM were excluded. Patients did not receive any other prophylactic antibiotic. The outcome variables included presence of febrile morbidity, endometritis, and wound infection. Data was analyzed by SPSS software (version 11.5) and P-value Findings: Febrile disorder and endometritis were found in 5 (3.4%) patients who had received Metronidazole gel and 16 (11%) who had received placebo gel (P = 0.001). 11 (7.5%) patients receiving Metronidazole gel and 19 (13%) ones receiving placebo gel encountered wound infection (P = 0.001). Conclusion: The preoperative administration of intra-vaginal Metronidazole gel appears to reduce the incidence of post-cesarean endometritis. Key Words: Metronidazole Gel, Post-Cesarean Endometritis, Prevention.
Full-Text [PDF 293 kb]   (6 Downloads)    
Type of Study: Research | Subject: General
Received: 2022/03/15


XML   Persian Abstract   Print



Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 27, Issue 92 (5-2009) Back to browse issues page